Analysis of Various Opiates including Hydrocodone or Hydromorphone in Biosamples by Gc/ms after Silylation
نویسندگان
چکیده
A GC/MS method suitable to conduct practical toxicological analyses of unspecified opiates including hydrocodone or hydromorphone is presented. Silylation can be a convenient reaction to derivatize unknown analytes in toxicological samples. However, silylation of drugs with tautomeric keto/enol groups in molecular structure can cause analytical problems due to poor reproducibility. After using N-methyl-N-trimethylsilyltrifluoracetamide (MSTFA) acceptable results were achieved.
منابع مشابه
Hydromorphone and hydrocodone interference in GC/MS assays for morphine and codeine.
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